PRP Therapy
Rejuvenating Ovary & Uterine Lining
Innovative solution for women’s infertility
Platelet-rich plasma (PRP)
Platelet-rich plasma (PRP) is an autologous blood product consisting of a highly concentrated preparation of platelets in a small volume of plasma.
Hundreds of bioactive molecules such as growth factors (platelet-derived growth factor, transforming growth factor-b, vascular endothelial growth factor, epidermal growth factor, and fibroblast growth factor), cytokines, and cell adhesion molecules are stored within platelets’ a granules.
The release of the a granules from activated platelets allows the delivery of these factors at high concentrations to target tissues, resulting in the stimulation of cell proliferation and differentiation, angiogenesis, and chemotaxis as well as modification of the local immune response.
Currently, PRP is used in a variety of clinical settings and emerging data have also shown a benefit in in vitro fertilization transfers for women with a thin endometrium.
Platelet-rich plasma (PRP) is an autologous product acquired from whole blood through the laboratory process and treatments represent one of the breakthroughs in medical science over last 15 years bequeathing a pathway for people suffering from several musculoskeletal and infertility issues with a possible relief of their symptoms.
Flow Chart
Procedure of Intrauterine Infusion
Reference
Turocy, J., et al., 2021; Nazari, L., et al., 2020; Nazari, L., et al., 2019; Chang, Y., et al., 2019; Kim, H., et al., 2019; Sefrioui, O. et al., 2019; Sfakianoudis, K et al., 2018; Kramer, M. E., et al., 2018; Eftekhar, M., et al., 2018 ; Zadehmodarres, S., et al., 2017
Turocy, J., & Williams, Z. (2021). Novel therapeutic options for treatment of recurrent implantation failure. Fertility and sterility, 116(6), 1449-1454.
Nazari, L., Salehpour, S., Hosseini, M. S., & Hashemi Moghanjoughi, P. (2020). The effects of autologous platelet-rich plasma in repeated implantation failure: a randomized controlled trial. Human Fertility, 23(3), 209-213.
Nazari, L., Salehpour, S., Hoseini, S., Zadehmodarres, S., & Azargashb, E. (2019). Effects of autologous platelet-rich plasma on endometrial expansion in patients undergoing frozen-thawed embryo transfer: A double-blind RCT. International Journal of Reproductive BioMedicine, 17(6), 443.
Chang, Y., Li, J., Wei, L. N., Pang, J., Chen, J., & Liang, X. (2019). Autologous platelet-rich plasma infusion improves clinical pregnancy rate in frozen embryo transfer cycles for women with thin endometrium. Medicine, 98(3).
Kim, H., Shin, J. E., Koo, H. S., Kwon, H., Choi, D. H., & Kim, J. H. (2019). Effect of autologous platelet-rich plasma treatment on refractory thin endometrium during the frozen embryo transfer cycle: a pilot study. Frontiers in endocrinology, 10, 61.
Sefrioui, O., Madkour, A., Bouamoud, N., Kaarouch, I., Saadani, B., Amzazi, S., … & with the Lorem Ipsum Consortium. (2019). Luteal progesterone level correlated with immunotherapy success of patients with repeated implantation failures. bioRxiv, 603720.
Sfakianoudis, K., Simopoulou, M., Nitsos, N., Rapani, A., Pappas, A., Pantou, A., … & Pantos, K. (2018). Autologous platelet-rich plasma treatment enables pregnancy for a woman in premature menopause. Journal of clinical medicine, 8(1), 1.
Kramer, M. E., & Keaney, T. C. (2018). Systematic review of platelet‐rich plasma (PRP) preparation and composition for the treatment of androgenetic alopecia. Journal of cosmetic dermatology, 17(5), 666-671.
Eftekhar, M., Neghab, N., Naghshineh, E., & Khani, P. (2018). Can autologous platelet rich plasma expand endometrial thickness and improve pregnancy rate during frozen-thawed embryo transfer cycle? A randomized clinical trial. Taiwanese Journal of Obstetrics and Gynecology, 57(6), 810-813.
Zadehmodarres, S., Salehpour, S., Saharkhiz, N., & Nazari, L. (2017). Treatment of thin endometrium with autologous platelet-rich plasma: a pilot study. JBRA assisted reproduction, 21(1), 54.
