PBMC Therapy
Rejuvenating Ovary & Uterine Lining
Innovative solution for women’s infertility
PBMC Therapy
Flow Chart
Procedure of Intrauterine Infusion
- • After antagonist ovarian stimulation protocol,
- The blood sample is scheduled on a specific day to isolate PBMCs
- PBMCs prepared in Laboratory
- Then PBMC will transfer inside the uterine cavity with the help of an ET catheter two days before embryo transfer.
- After embryo transfer, patients receive oral Utrogestan (Micronised Progesterone) 200 mg_2/day for luteal support.
Reference
Turocy, J., & Williams, Z. (2021). Novel therapeutic options for treatment of recurrent implantation failure. Fertility and sterility, 116(6), 1449-1454.
Sefrioui, O., Madkour, A., Bouamoud, N., Kaarouch, I., Saadani, B., Amzazi, S., … & with the Lorem Ipsum Consortium. (2019). Luteal progesterone level correlated with immunotherapy success of patients with repeated implantation failures. BioRxiv, 603720.
Yu, N., Zhang, B., Xu, M., Wang, S., Liu, R., Wu, J., … & Feng, L. (2016). Intrauterine administration of autologous peripheral blood mononuclear cells (PBMC s) activated by HCG improves the implantation and pregnancy rates in patients with repeated implantation failure: a prospective randomized study. American Journal of Reproductive Immunology, 76(3), 212-216.
Madkour, A., Bouamoud, N., Louanjli, N., Kaarouch, I., Copin, H., Benkhalifa, M., & Sefrioui, O. (2016). Intrauterine insemination of cultured peripheral blood mononuclear cells prior to embryo transfer improves clinical outcome for patients with repeated implantation failures. Zygote, 24(1), 58-69.
Fujiwara, H. (2006). Immune cells contribute to systemic cross‐talk between the embryo and mother during early pregnancy in cooperation with the endocrine system. Reproductive medicine and biology, 5(1), 19-29.
